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KMID : 0352720110350020250
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Journal of Ginseng Research
2011 Volume.35 No. 2 p.250 ~ p.255
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Therapeutic Effect of Korean Red Ginseng Extract on Infertility Caused by Polycystic Ovaries
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Jung Ji-Hun
Park Hyun-Tae
Kim Tak
Jeong Moon-Jin
Lim Sung-Chul
Nah Seung-Yeol
Cho Ik-Hyun
Park Soo-Hyun
Kang Seong-Soo
Moon Chang-Jong
Kim Jong-Choon
Kim Sung-Ho
Bae Chun-Sik
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Abstract
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Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 ㎎/㎏ body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.
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KEYWORD
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Panax ginseng, Polycystic ovary syndrome, Estradiol valerate, Pathophysiology, Ginseng extract
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